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Notably, current evidence strongly supports the notion that human macrophages generate nitric oxide and reactive species in vivo 62

The combined effect: a bottle that should be good for 28 days can be unsafe at day 10 if multiple failure modes stack

Similarly, many probiotic strains are killed off by stomach acid before they reach the lower intestine

This, in turn, may disrupt the hypothalamic-pituitary-adrenal (HPA) axis, leading to elevated cortisol levels and contributing to anxiety and repetitive behaviors